Importance of Strengthening Healthy and balanced Life | Healthuse ...

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Source: http://www.healthuse.com/importance-of-strengthening-healthy-and-balanced-life.html

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New genomics study shows ancestry could help solve disease riddles

ScienceDaily (Oct. 25, 2012) ? Explosive advancement in human genome sequencing opens new possibilities for identifying the genetic roots of certain diseases and finding cures. However, so many variations among individual genomes exist that identifying mutations responsible for a specific disease has in many cases proven an insurmountable challenge. But now a new study by scientists at The Scripps Research Institute (TSRI), Scripps Health, and Scripps Translational Science Institute (STSI) reveals that by comparing the genomes of diseased patients with the genomes of people with sufficiently similar ancestries could dramatically simplify searches for harmful mutations, opening new treatment possibilities.

The work, reported recently in the journal Frontiers in Genetics: Applied Genetic Epidemiology, should speed the search for the causes of many diseases and provide critical guidance to the genomics field for maximizing the potential benefits of growing genome databases.

Much work is already under way to sequence the DNA of people suffering from diseases with unknown causes, called idiopathic conditions, to find the roots of their problems. Unlike more complex conditions such as diabetes, in some cases a limited number of genetic defects, or even a single mutation, can cause an idiopathic disease. Identifying those critical mutations can lead to effective treatments for previously mysterious problems.

Complicated Searches

While there have been some successes, in many other instances the genetic basis of an idiopathic disease remains elusive. Among other groups, The National Human Genome Research Institute runs searches for idiopathic disease sufferers and is able to find offending gene sequences only about 30 percent of the time. "One explanation for that other 70 percent might be that the diseases are enormously complex," said the new study's senior author Nicholas Schork, a professor at TSRI, director of research for Scripps Health's genomic medicine program, and director of biostatistics and bioinformatics at STSI, "but it could be that they're still searching in the noise."

The new work offers a likely filter for much of that noise. The results show that comparing a person's DNA sequence against existing genomes for those whose ancestry is not sufficiently similar, as is typically the case, can cause serious problems. Countless differences that seem unique to a patient might instead be DNA variants carried by everyone with the same ancestry. A researcher might, for instance, identify hundreds of variants and not be able to zero in on the one responsible for a disease.

But the new results show that comparing closer ancestry matches will dramatically reduce the number of variants identified as potentially responsible for a disease, reducing a search to a workable number.

For the work, the team developed a tool called the Scripps Genome Adviser. This processing framework uses a supercomputer to incorporate a variety of databases and algorithms to identify DNA variants in a particular genome relative to reference genomes. It then uses algorithms to analyze these variants and predict whether they have any physiological effects, and if so what those might be.

The team began with nearly 60 whole human genome databases and ran three key types of computing experiments. First the researchers identified the number of variants in the reference human genomes and found that on average each has millions of variants, about 12,000 of which have functional effects. Then the scientists looked at the rates at which variants appeared in various ancestry lines.

Honoring Ancestry

Importantly, the scientists didn't stop there. They deliberately inserted a mutation known to cause disease into a genome, then ran this genome through the Adviser to see how effectively it could identify that known variant as unique.

When the team ran the searches comparing that altered genome against a reference panel of genomes that included different ancestries, the known variant remained effectively lost in a sea of other variants. But comparison against genomes of similar ancestry dramatically reduced the number of variants identified, allowing identification of the inserted disease-causing gene.

A study published simultaneously with the Scripps team's paper by Professor Carlos Bustamante and colleagues from Stanford University also pointed to ancestry's importance, but this is the first time a team has been able to look at the problem on the whole-genome scale. "Others have indeed recognized ancestry as important," said Schork, "but no one had shown how much it could haunt a particular study, especially on a whole genome basis."

As importantly, prior to this study it wasn't clear how to address the ancestry issue. But the new study provides clear direction. The team calculated that identification of the vast majority of ancestral variants can be performed successfully with a reference panel of less than 20 genomes -- though it could well take more to identify a particular ancestry group's rarest deviations. Of course, most people have more than one ancestry line, meaning that in practice a patient's reference panel would need to include multiple reference groups.

This result should act as a guide for continuing genomics work. Many ancestries are already well represented, meaning that assembling an effective reference panel is possible in some cases. But the number of whole genomes from a particular ancestral group isn't the only consideration. Ideally, reference genomes need to be from relatively disease-free people, meaning subjects who lived to an old age without major complications from genetic conditions.

Recognizing the importance of ancestral comparisons, researchers and companies can now deliberately work to fill any holes. "Building those sorts of resources could only benefit the community," said Schork. In fact, Schork, Ali Torkamani and others at Scripps are collaborating with Complete Genomics, Inc., a whole genome sequencing company in Mountain View, CA, to develop appropriate reference panels for clinicians and researchers.

Deciphering Diseases

Schork and his colleagues are already working toward broader application of their results using an increasingly advanced version of the tool. While processing a single person's genome to identify and analyze variants took about four days when the project began, today the Adviser can accomplish the task in about 30 minutes.

Along with the paper's lead author Torkamani, Schork is a founder of a company called Cypher Genomics that has licensed the Scripps Genome Adviser for disease-focused research. The teams in both industry and academia hope not only to continue idiopathic disease research, but also to apply similar principles to search for the causes of more complex congenital conditions. "The broader message of our work is that you have to take ancestry into account no matter what disease you're studying," said Schork.

This research was supported by the National Institutes of Health (grant numbers 5 UL1 RR025774, 5 U01 DA024417, 5 R01 HL089655, 5 R01 DA030976, 5 R01 AG035020, 1 R01 MH093500, 2 U19 AI063603, 2 U19 AG023122, 5 P01 AG027734, 1 U01 HG006476-01), the Stand Up to Cancer Foundation, the Price Foundation and Scripps Genomic Medicine.

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Story Source:

The above story is reprinted from materials provided by The Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Ali Torkamani, Phillip Pham, Ondrej Libiger, Vikas Bansal, Guangfa Zhang, Ashley A. Scott-Van Zeeland, Ryan Tewhey, Eric J. Topol and Nicholas Schork. Clinical Implications of Human Population Differences in Genome-wide Rates of Functional Genotypes. Front. Gene., 2012 DOI: 10.3389/fgene.2012.00211

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/Xeg5uqPNIPQ/121025152748.htm

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Durable orders show business investment still weak

WASHINGTON (AP) ? U.S. companies remained cautious in September and held back on orders for long-lasting manufactured goods that signal investment plans. Weak business investment has contributed to slower economic growth.

The Commerce Department said Thursday that orders for durable goods jumped 9.9 a percent last month. While it was the biggest gain in nearly three years, most of the September gain was driven by a tremendous spike in aircraft orders, which are very volatile and plummeted in the previous month.

When taking out transportation, orders rose just 2 percent. And demand for core capital goods, such as machinery and equipment, were unchanged in September. Core capital goods are considered a proxy for business investment plans. Those orders rose only slightly in August after steep declines in July and June.

Peter Newland, an economist at Barclays, said the report "painted a soft picture of business demand" in the July-September quarter. He said the weakness had prompted him to trim his estimate for economic growth in the quarter from 2 percent down to 1.8 percent.

Durable goods are products expected to last at least three years. Orders can fluctuate sharply from month to month.

Demand is sharply lower this year, which has weakened manufacturing and hampered economic growth. High unemployment and low pay have kept consumers from spending. Businesses have held back on investing in machinery and equipment. And slower global growth has dampened demand for U.S. exports.

Economists are concerned that businesses could pull back further if Congress doesn't reach an agreement to avert steep tax hikes and government spending cuts scheduled to take effect in January.

There is some indication that U.S. factory activity could be improving. A closely watched survey from the Institute for Supply Management, said manufacturing grew in September for the first time in four months. It was buoyed by a jump in new orders.

Americans also boosted their spending at retail businesses in September, buying more cars, appliances and furniture. Stronger consumer spending could help offset declining demand from overseas.

Still, the decline in U.S. manufacturing has slowed job growth. Manufacturing employment dropped by 16,000 in September after falling by 22,000 in August.

The weak job market has been a key topic in this year's presidential election, which is down to its final days. Voters will have one final employment report to consider, which comes out four days before Election Day.

The economy is not growing fast enough to generate much hiring. Growth slowed to a tepid annual rate of 1.3 percent in the April-June quarter, down from 2 percent in the previous quarter. Most economists see growth staying at or below 2 percent in the second half of the year. The Commerce Department will issue its first estimate of growth in the July-September quarter on Friday.

Source: http://news.yahoo.com/durable-orders-show-business-investment-still-weak-132239877--finance.html

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'Jesus,' 'ninja,' among worst passwords of 2012

3 hrs.

Suzanne Choney , NBC News

The next time you're asked to create?an 8-character password, don't choose "password." Despite it being the among worst possible choices, it remains the most common password?used on the Internet and posted by hackers.

No. 2 and No. 3, respectively are the tried-and-true weaklings?"123456" and "12345678." (Those two mean you can count???on being low-hanging fruit for hackers, that is.)

The info?comes from?SplashData, which makes password management applications. The company's?top 25 list of the "scariest" passwords was released with?Halloween as a peg, but there's no treats here for anyone, and possibly some nasty tricks.

The list was put together "from?files containing millions of stolen passwords posted online by hackers," SplashData says. If you use any of the passwords on the list, you should change them immediately. Otherwise, users "of any of these passwords are most likely to be victims in future breaches," the company says.

While "password," "123456" and "12345678" remain the top three again from last year's list, newcomers include?"welcome, " "jesus," "ninja," "mustang" and the brilliant?"password1."?

Here's the top 25 "Worst Passwords of 2012," including their current ranking and any change from the 2011 list:?

1. ?password (Unchanged)
2, ?123456 (Unchanged)
3. ?12345678 (Unchanged)
4. ?abc123 (up 1)
5. ?qwerty (down 1)
6. ?monkey (unchanged)
7. ?letmein (up 1)
8. ?dragon (up 2)
9. ?111111 (up 3)
10. baseball (up 1)
11. iloveyou (up 2)
12. trustno1 (down 3)
13. 1234567 (down 6)
14. sunshine (up 1)
15. master (down 1)
16. 123123 (up 4)
17. welcome (new)?
18. shadow (up 1)
19. ashley (down 3)
20. football (up 5)
21. jesus (new)
22. michael (up 2)
23. ninja ?(new)
24. mustang (new)
25. password1 (new)

"At this time of year, people enjoy focusing on scary costumes, movies and decorations, but those who have been through it can tell you how terrifying it is to have your identity stolen because of a hacked password,? said Morgan Slain, SplashData CEO, in a statement.?

?Even though each year hacking tools get more sophisticated, thieves still tend to prefer easy targets,? he said. ?Just a little bit more effort in choosing better passwords will go a long way toward making you safer online.?

Check out Technolog, Gadgetbox, Digital Life and In-Game on?Facebook,?and on?Twitter, follow Suzanne Choney.

Source: http://www.nbcnews.com/technology/technolog/jesus-ninja-join-password-worst-passwords-2012-1C6643652

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Anthropologist finds evidence of hominin meat eating 1.5 million years ago: Eating meat may have 'made us human'

ScienceDaily (Oct. 3, 2012) ? A skull fragment unearthed by anthropologists in Tanzania shows that our ancient ancestors were eating meat at least 1.5 million years ago, shedding new light into the evolution of human physiology and brain development.

"Meat eating has always been considered one of the things that made us human, with the protein contributing to the growth of our brains," said Charles Musiba, Ph.D., associate professor of anthropology at the University of Colorado Denver, who helped make the discovery. "Our work shows that 1.5 million years ago we were not opportunistic meat eaters, we were actively hunting and eating meat."

The study was published October 3 in the peer-reviewed journal PLOS ONE.

The two-inch skull fragment was found at the famed Olduvai Gorge in northern Tanzania, a site that for decades has yielded numerous clues into the evolution of modern humans and is sometimes called `the cradle of mankind.'

The fragment belonged to a 2-year-old child and showed signs of porotic hyperostosis associated with anemia. According to the study, the condition was likely caused by a diet suddenly lacking in meat.

"The presence of anemia-induced porotic hyperostosis?indicates indirectly that by at least the early Pleistocene meat had become so essential to proper hominin functioning that its paucity or lack led to deleterious pathological conditions," the study said. "Because fossils of very young hominin children are so rare in the early Pleistocene fossil record of East Africa, the occurrence of porotic hyperostosis in one?suggests we have only scratched the surface in our understanding of nutrition and health in ancestral populations of the deep past."

Musiba said the evidence showed that the juvenile's diet was deficient in vitamin B12 and B9. Meat seems to have been cut off during the weaning process.

"He was not getting the proper nutrients and probably died of malnutrition," he said.

The study offers insights into the evolution of hominins including Homo sapiens. Musiba said the movement from a scavenger, largely plant-eating lifestyle to a meat-eating one may have provided the protein needed to grow our brains and give us an evolutionary boost.

Some scientists have argued that we became human when we became carnivorous-omnivorous creatures.

"Meat eating is associated with brain development," he said. "The brain is a large organ and requires a lot of energy. We are beginning to think more about the relationship between brain expansion and a high protein diet."

Humans are one of the few surviving species with such a large brain to body size ratio. Chimpanzees, our closest relatives, eat little meat and have far less brain capacity than humans, Musiba said.

"That separates us from our distant cousins," he said. "The question is what triggered our meat eating? Was it a changing environment? Was it the expansion of the brain itself? We don't really know."

Four students participating in the CU Denver Tanzania Field School were at Olduvai Gorge when the skull fragment was discovered.

"It was a great experience for them," said Musiba, director of the Field School and a native of Tanzania. "Hopefully, it will inspire even more students to come to Africa and help us find answers to the questions posed by these discoveries."

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The above story is reprinted from materials provided by University of Colorado Denver, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Manuel Dom?nguez-Rodrigo, Travis Rayne Pickering, Fernando Diez-Mart?n, Audax Mabulla, Charles Musiba, Gonzalo Trancho, Enrique Baquedano, Henry T. Bunn, Doris Barboni, Manuel Santonja, David Uribelarrea, Gail M. Ashley, Mar?a del Sol Mart?nez-?vila, Rebeca Barba, Agness Gidna, Jos? Yravedra, Carmen Arriaza. Earliest Porotic Hyperostosis on a 1.5-Million-Year-Old Hominin, Olduvai Gorge, Tanzania. PLoS ONE, 2012; 7 (10): e46414 DOI: 10.1371/journal.pone.0046414

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/5sZeocC8kFY/121004093508.htm

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Samsung Galaxy Note II LTE Added To U.K. Carrier EE?s 4G Handset Launch Line-Up

Customers of U.K. carriers Orange and T-Mobile keen to sign up to the country's first 4G LTE network (launching from EE), which will go live in ten cities on October 30, will need an LTE handset to do so. EE, the parent company of the Orange, T-Mo joint venture, has today announced it's adding Samsung's latest phablet phone -- the Galaxy Note II LTE -- to its launch line-up of 4G-ready handsets.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/YkUt_HoPpo8/

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Clinton: Iran responsible for its economic problems, plunging currency, rising protests

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Viking Global looking for a strong run in Bet on your mobile - Bettor

Viking Global looking for a strong run in Bet on your mobile @ Williamhill.com Stakes

Viking Global missed out on a Grade A2 victory last time around, but she has a solid chance of making her team proud in the Bet on your mobile @ Williamhill.com Stakes at Newcastle in England on Tuesday, October 2, 2012. She is a very good runner and has been challenging her opponents with consistency since making her debut in the sport.

Therefore, it will be extremely difficult to stop the young bitch from taking the top spot in the Grade A2 contest, which is scheduled to kick off at 19:32 GMT. She has got both the speed and stamina to outperform her rivals in the 480 metres event, which will earn her a cash prize of ?127 in the end.

However, there are some other solid contenders for victory in the race as well and they will not make life easy for the rest of the greyhounds. One of them is Fagans Guest, who has been rated as the favourite to succeed. He has been given a general starting price of 5 to 2 and will definitely get the attention of the punters.

Furthermore, the seasoned dog will be starting the race from trap number six, which will give him an opportunity of attacking from the start. If he is quick out of the blocks, his opponents will not find it easy to catch him towards the end.

However, the J. Fenwick?s trained hound was unable to deliver a strong result from a similar position in his most recent outing, thus he will be low on confidence. He was rated as the favourite to succeed back then as well, but disappointed his fans with a fourth place finish in the end.

On the other hand, Viking Global ran extremely well in her most recent race and she will be full of confidence at the moment. She was up against some quality runners and was not given the best odds for victory.

Despite that, the D. Calvert?s trained bitch gave a tough time to her opponents and finished in second place by just three quarters. She will be looking to attack everyone in order to pressurise them, but she will be starting from trap number four and will have to be extremely careful about everything.

Disclaimer: The views expressed in this article are solely of the writer?s and do not reflect bettor.com?s official editorial policy.

Source: http://blogs.bettor.com/Viking-Global-looking-for-a-strong-run-in-Bet-on-your-mobile-Williamhill-com-Stakes-a191783

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NYSF In Asheville: El Kimchi Korean BBQ | New York Street Food

(credit: NYSF)

So, we?re in Asheville, NC visiting family for a few days, which gave us an opportunity to check out the food truck scene here.

Every locale has their own push and pull between brick-and-mortar, food trucks, and local government. In NYC, it?s basically a free-for-all.

In Asheville, food trucks are confined to one parking lot in town (away from the restaurants), but there can be anywhere from 2-4 trucks in the lot, and they rotate daily.?The first food truck we tried was El Kimchi Korean BBQ.

The menu was truly a fusion of Korean and Mexican, with tacos, burritos, tortas and quesadillas, as well as bibimbap and rice bowls. We got 3 tacos for $5 (yes, we?re not in New York anymore). We also got the Daily Special, goon mandu, which was an order of 6 dumplings for $5.

(credit: NYSF)

The goon mandu were pan-fried dumplings, which came out piping hot. Inside the dumplings was a combination of pork, tofu and veggies that was more along the veggie line. The filling was finely minced, but the pork wasn?t readily apparent to our taste.

The goon mandu came with a soy & sesame dipping sauce that we liked. It wasn?t a strong dipping sauce, but added a nice flavor to the dumplings.

There were 5 choices for taco fillings, and we got spicy pork, beef bulgogi and chicken teriyaki.

(credit: NYSF)

The tacos came with lots of shredded lettuce, pico de gallo, homemade kimchi, and a lime wedge, plus the meats underneath.

These were tasty Korean tacos. The meats were very flavorful, from the spiciness of the pork, to the marinated beef bulgogi and the teriyaki chicken.

You can?t see the the meats under all the lettuce, but they came through loud and clear.

About the only downside was the single corn tortilla. There was so much stuffed into the taco, you really needed two tortillas to handle it all comfortably.

Overall, this was an enjoyable lunch of Korean tacos and dumplings. The proprietor told us there were currently no Korean restaurants in Asheville, but we would beg to differ.

El Kimchi Korean BBQ may not be a brick-and-mortar restaurant, but it is certainly an excellent place to get Korean food in Asheville.

You can find the El Kimchi facebook here and twitter here.

(credit: NYSF)

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This entry was posted on Tuesday, October 2nd, 2012 at 2:30 pm and is filed under Street Food. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

Source: http://newyorkstreetfood.com/35906/nysf-in-asheville-el-kimchi-korean-bbq/

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